Post-Transcriptional Regulatory Mechanisms (PTRM)
Coursemasters:
David M. Bedwell, Ph.D.
Sunnie Thompson, Ph.D.

Journal Club Speaker Schedule
Spring 2009
Date Speaker Paper
01/07/09 Shane Kelly Translational bypassing without peptidyl-tRNA anticodon scanning of coding gap mRNA. EMBO J. 27: 2533 (09)
01/14/09 Marla Hertz A protein that replaces the entire cellular eIF4F complex. EMBO J. 27: 3129-39 (2008).
01/21/09 Dan Wang The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease...Nucleic Acids Res. (Epub 09)
01/28/09 Alison Dean Yeast ribosomal protein L10 helps coordinate tRNA movement through... Nucleic Acids Res. 36: 6187-98 (08).
02/04/09 Sara Conard Regulation of ARE transcript 3' end processing by the yeast Cth2 mRNA decay factor. EMBO J. 27: 2966-76.
02/11/09 Dori Landry An unexpected type of ribosomes induced by Kasugamycin: A look into ancestral...Mol. Cell 33: 227-36 (2009).
Supplementary Information
02/18/09 Wei-Jye Lin DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating ...Mol. Cell 32: 371-82 (2008).
02/25/09 Shane Kelly The Native 3D Organization of Bacterial Polysomes. Cell 136: 261-71 (2009).
03/04/09 Marla Hertz Quality control by the ribosome following peptide bond formation. Nature 457: 161-8 (2009).
03/11/09 Dan Wang Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature 457: 736-41 (2009).
03/18/09 Alison Dean The importance of inter- and intramolecular base pairing for translation ...Genes & Dev. 23: 331-44 (2009).
03/25/09 Sara Conard Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated ...Mol. Cell. Biol. 29: 1152-62 (2009).
04/01/09 Dori Landry A Novel Function for Fragile X Mental Retardation Protein in Translational Activation PLoS 7: 0133 (2009).
04/08/09 Wei-Jye Lin Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translation Repression. Mol. Cell (09).
04/15/09 Shane Kelly Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein...J. Biol. Chem. 284: 10343 (09)
04/22/09 Marla Hertz General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J. (09).
04/29/09 Dan Wang Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution...Science 324: 218 (09).
     
Tuesday @ 10:30 a.m.
Fall 2009
Date Speaker Paper
09/01/09 Shane Kelly Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2. Mol. Cell 35: 316-26 (09).
09/08/09 Wei-Jye Lin The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459: 1010 (09).
09/15/09 Sara Conard Co-translational mRNA decay in Saccharomyces cerevisiae. Nature 461: 225-30. (09).
09/22/09 Alison Dean Essential role for elF4GI overexpression in the pathogenesis of inflammatory... Nature Cell Biol. 11: 903 (09).
09/29/09 Dan Wang Widespread Shortening of 3'UTRs by Alternative Cleavage and Polyadenylation...Cell 138: 673-84 (09).
10/06/09 Dori Landry The SESA network links duplication of the yeast centrosome with the protein... Genes & Dev. 23: 1559-70 (09).
10/13/09 Group Mammalian miRNA RISC Recruits CAF1 and PABP to Affect...Mol. Cell 35: 868-80 (09). (Suppl) / (Preview)
10/20/09 Shane Kelly Misfolded proteins partition between two distinct quality control compartments. Nature 454: 1088-96 (09). Suppl
10/27/09 Wei-Jye Lin Multivesicular bodies associate with components of miRNA effector complexes...Nat. Cell Biol. 11: 1143 (09).
11/03/09 Sara Conard RNAi in Budding Yeast. Science 326: 544 (09). (Suppl)
11/10/09 Dan Wang The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates...Cell: 139: 547-59 (09).
11/17/09 Alison Dean Immature small ribosomal subunits can engage in translation initiation... EMBO J. (09).
11/24/09 Dori Landry Rational Extension of the Ribosome Biogenesis Pathway Using... PLoS Biology 7: e1000213 (09).
12/01/09 Group  
Possible Topics: mRNA maturation
mRNA export from the nucleus
mRNA turnover
AU Rich elements (AREs)
Translational regulation
Regulated protein turnover
ER stress (regulated protein folding)
Genetic recoding (frame shifting, RNA editing, etc.)
Ribosome structure/function
  IRES function
 
Click here for previous schedule
Revised last: Friday, November 20, 2009