Post-Transcriptional Regulatory Mechanisms (PTRM)
Coursemasters:
David M. Bedwell, Ph.D.
Sunnie Thompson, Ph.D.

Journal Club Speaker Schedule
Fall 2008
Date Speaker Paper
08/26/08 Marla Hertz HCV and CSFV IRES domain II mediate elF2 release during 80S ribosome assembly - EMBO J. 26: 795-805 (07)
09/02/08 Sara Conard Puf1p acts in combination with other yeast Puf proteins to control mRNA stability - RNA: 14: 246-62. 
09/09/08 Dan Wang The mRNA Export Factor Gle1 and Inositol Hexakisphosphate Regulate Distinct Stages - Cell 134: 624-33.
09/16/08 Marla Hertz Genetic identification of yeast 18S rRNA residues required... - Genes & Dev. 22: 2242-55 (2008)
09/23/08 Wei-Jye Lin p53 mRNA controls p53 activity by managing Mdm2 functions - Nat. Cell Biol. 10: 1098-1105 (2008)
09/30/08 Shane Kelly Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions... Science 320: 1643 (2008)
10/07/08 Alison Dean Translation initiation by the c-myc mRNA internal ribosome entry sequence... RNA 14: 1579-89 (2008)
10/14/08   No Meeting
10/21/08 Dan Wang eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning...Genes & Dev. 22: 2414-25.
10/28/08 Shane Kelly Mature ribosomes are selectively degraded upon starvation by an autophagy...Nature Cell Biol. 10: 602-10 (2008).
11/04/08 Charu Shukla Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association... RNA 14: 1950-58 (2008)
11/11/08 Sara Conard The DEAD-Box RNA Helicase Ded1p Affects and Accumulates in... Mol. Cell. Biol. 19: 984-93 (2008).
11/18/08 Wei-Jye Lin Posttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops Cell 32: 383-93 (2008).
11/25/08 Charu Shukla Widespread Impact of Nonsense-Mediated mRNA Decay on the Yeast Intronome. Mol. Cell 31: 360-70 (2008).
12/02/08 Alison Dean Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature (Epub 2008).
     
Wednesday @ 10:30 a.m.
Spring 2009
Date Speaker Paper
01/07/09 Shane Kelly Translational bypassing without peptidyl-tRNA anticodon scanning of coding gap mRNA. EMBO J. 27: 2533 (09)
01/14/09 Marla Hertz A protein that replaces the entire cellular eIF4F complex. EMBO J. 27: 3129-39 (2008).
01/21/09 Dan Wang The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease...Nucleic Acids Res. (Epub 09)
01/28/09 Alison Dean Yeast ribosomal protein L10 helps coordinate tRNA movement through... Nucleic Acids Res. 36: 6187-98 (08).
02/04/09 Sara Conard Regulation of ARE transcript 3' end processing by the yeast Cth2 mRNA decay factor. EMBO J. 27: 2966-76.
02/11/09 Dori Landry An unexpected type of ribosomes induced by Kasugamycin: A look into ancestral...Mol. Cell 33: 227-36 (2009).
Supplementary Information
02/18/09 Wei-Jye Lin DAPK-ZIPK-L13a Axis Constitutes a Negative-Feedback Module Regulating ...Mol. Cell 32: 371-82 (2008).
02/25/09 Shane Kelly The Native 3D Organization of Bacterial Polysomes. Cell 136: 261-71 (2009).
03/04/09 Marla Hertz Quality control by the ribosome following peptide bond formation. Nature 457: 161-8 (2009).
03/11/09 Dan Wang Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature 457: 736-41 (2009).
03/18/09 Alison Dean The importance of inter- and intramolecular base pairing for translation ...Genes & Dev. 23: 331-44 (2009).
03/25/09 Sara Conard Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated ...Mol. Cell. Biol. 29: 1152-62 (2009).
04/01/09 Dori Landry A Novel Function for Fragile X Mental Retardation Protein in Translational Activation PLoS 7: 0133 (2009).
04/08/09 Wei-Jye Lin Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translation Repression. Mol. Cell (09).
04/15/09 Shane Kelly Nascent Peptide-dependent Translation Arrest Leads to Not4p-mediated Protein...J. Biol. Chem. 284: 10343 (09)
04/22/09 Marla Hertz General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. EMBO J. (09).
04/29/09 Dan Wang Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution...Science 324: 218 (09).
     
Possible Topics: mRNA maturation
mRNA export from the nucleus
mRNA turnover
AU Rich elements (AREs)
Translational regulation
Regulated protein turnover
ER stress (regulated protein folding)
Genetic recoding (frame shifting, RNA editing, etc.)
Ribosome structure/function
  IRES function
 
Click here for previous schedule
Revised last: Wednesday, June 3, 2009