Recent Recognition in Journals and Science Press:
Clinical Snippets: [J. Invest. Dermatology 126: 2 (2006)]
News Feature: [Nature 438: 8 (2005)]
Clinical Implications: [J Mol. Med. 80: 543-544 (2002)]
Medical News and Perspectives: [J. Am. Med. Assn. 285: 2067-2068 (2001)]
Commentary: [The Lancet: 358: 2014-2015 (2001)]
Recent Recognition in Lay Press:
Bedwell wins Henze award for CF research (2008)
Science Daily (2008)
Medical News Today (2008)
PTC Therapeutics News (2008)
BioWorld Today (2008)
News-Medical.Net (2008)
Canadian Cystic Fibrosis Foundation (2008)
Scientist Live (2008)
Bio-Medicine (2008)
Newswise: Drug Fights Cystic Fibrosis (2008)
United Press International: Cystic fibrosis may be treated with drug (2008)
New York Academy of Science: eBriefing from Beast in the Genomic Jungle: Use of Model Organisms in Drug Discovery (2007)
Television news story on Bedwell Lab research produced by Ivanhoe news (2003)
The Scientist (2001)
Recent Publications:
Fan-Minogue, H., Du, M., Pisarev, A.V., Kallmeyer, A.K., Salas-Marco, J., Keeling, K.M., Thompson, S.R., Pestova, T.V., and Bedwell, D.M. (2008) Distinct eRF3 Requirements Suggest Alternate eRF1 Conformations Mediate Peptide Release during Eukaryotic Translation Termination. Mol. Cell 30: 599-609. (Abstract) (PDF local)
Du, M., Liu, X., Welch, E.M., Hirawat, S., Peltz, S.W., and Bedwell D.M. (2008) PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse model. PNAS 105: 2064-9. (Abstract) (PDF local)
Fan-Minogue, H., and Bedwell, D.M. (2007) Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity. RNA 14: 184-57. (Abstract) (PDF local)
Kallmeyer, A., Keeling, K., and Bedwell, D. (2006) Eukaryotic release factor 1 phosphorylation by CK2 protein kinase is dynamic but has little effect on the efficiency of translation termination in Saccharomyces cerevisiae. Euk. Cell 5: 1378-87. (Abstract) (PDF local)
Keeling, K., Salas-Marco, J., Osherovich, L. and Bedwell, D.  (2006) Tpa1 is part of an mRNP complex that influences translation termination, mRNA deadenylation and mRNA turnover in Saccharomyces cerevisiae. Mol. Cell. Biol. 26: 5237-48. (Abstract) (PDF local)
Du, M., Keeling, K., Fan, L., Liu, X., Kovacs, T., Sorscher, E., and Bedwell, D.  (2006) Clinical doses of amikacin correct the CFTR-G542X stop mutation more efficiently than gentamicin in a transgenic CF mouse model. J. Mol. Med. 84: 573-82. (Abstract) (PDF local)
Kellermayer, R., Szigeti, R., Keeling, K., Bedekovics, T. and Bedwell, D. (2006) Aminoglycosides as potential pharmacogenetic agents in the treatment of Hailey-Hailey disease.  J. Invest. Dermatology 126: 229-31. (Abstract) (PDF local)
Keeling, K., Du, M. and Bedwell, D.  (2006) Therapies of nonsense-associated diseases, In “Nonsense-Mediated mRNA Decay”, L.E. Maquat, Ed., Landes Bioscience, pages 121-36. (Abstract) (PDF local)
Salas-Marco, J., Kallmeyer, A., Fan, H., Klobutcher, L., Farabaugh, P., and Bedwell, D.  (2006) Distinct paths to stop codon reassignment in the ciliates Tetrahymena and Euplotes.  Mol. Cell Biol. 26: 438-47. (Abstract) (PDF local)
Keeling, K and Bedwell, D. (2005) Pharmacological suppression of premature stop mutations that cause genetic diseases. Current Pharmacogenomics 3: 259-69. (Abstract) (PDF local)
Salas-Marco J, Bedwell DM. (2005) Discrimination between defects in elongation fidelity and termination efficiency provides mechanistic insights into translational readthrough. J. Mol. Biol. 348: 801-15. (Abstract) (PDF local)
Csutora, P., Strassz, A., Boldizsar, F., Nemeth, P., Sipos, K., Aiello, D.P., Bedwell, D.M., Miseta, A. (2005) Inhibition of Phosphoglucomutase Activity by Lithium Alters Cellular Calcium Homeostasis and Signaling in Saccharomyces cerevisiae. Am. J. Physiol. Cell Physiol. 289: 58-67. (Abstract) (PDF local)
Salas-Marco, J., Bedwell, D.M. (2004) GTP Hydrolysis by eRF3 Facilitates Stop Codon Decoding during Eukaryotic Translation Termination. Mol. Cell Biol. 24(17):7769-78. (Abstract) (PDF local)
Aiello, D.P., Fu, L., Miseta, A., Sipos, K., Bedwell, D.M. (2004) The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p. J. Biol. Chem. 279(37): 38495-502. (Abstract) (PDF local)
Keeling, K.M., Lanier, J., Du, M., Salas-Marco, J., Gao, L., Kaenjak-Angeletti, A., Bedwell, D.M. (2004) Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae. RNA 10(4):691-703. (Abstract) (PDF local)
Miseta, A., Tökés-Fûzesi, M., Aiello, D., and Bedwell, D. (2003) A yeast mutant unable to convert glucose to glucose-6-phosphate accumulates excessive glucose in the endoplasmic reticulum due to core oligosaccharide trimming. Euk. Cell 2: 534-41. (Abstract) (PDF local)
Kellermayer, R., Aiello, D.P., Miseta, A., Bedwell, D.M. (2003) Extracellular Ca(2+) sensing contributes to excess Ca(2+) accumulation and vacuolar fragmentation in a pmr1Delta mutant of S. cerevisiae. J. Cell Sci. 116:1637-46. (Abstract) (PDF local)
Aiello, D.P, Fu, L., Miseta, A., Bedwell, D.M. (2002) Intracellular Glucose-1-Phosphate and Glucose-6-Phosphate Levels Modulate Ca2+ Homeostasis in Saccharomyces cerevisiae. J. Biol. Chem. 277: 45751-8. (Abstract) (PDF local)
Keeling, K. and Bedwell, D. (2002) Clinically relevant aminoglycosides can suppress disease-causing translation termination mutations in the IDUA and P53 cDNAs in a mammalian translation system. J. Mol. Med. 80: 367-76. (Abstract) (PDF local)
Du, M., Jones, J.R., Lanier, J., Keeling, K.M., Lindsey, J.R., Tousson, A., Bebok, Z., Whitsett, J.A., Dey, C.R., Colledge, W.H., Evans, M.J., Sorscher, E.J., Bedwell, D.M. (2002) Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene. J. Mol. Med. 80: 595-604. (Abstract) (PDF local)
Tokes-Fuzesi, M., Bedwell, D.M., Repa, I., Sipos, K., Sumegi, B., Rab, A., Miseta, A. (2002) Hexose phosphorylation and the putative calcium channel component Mid1p are required for the hexose-induced transient elevation of cytosolic calcium response in Saccharomyces cerevisiae. Mol. Microbiol. 44: 1299-1308. (Abstract) (PDF local)
Current Grants:
NIH, David Bedwell, Ph.D., P.I. "Suppression of the Idua-W402X Mutation in an MPS I-H Mouse" 2/1/07-1/31/12. NIH, David Bedwell, Ph.D., P.I. "Mechanism of eukaryotic translation termination" 6/1/03-11/30/11.
NIH, David Bedwell, Ph.D., P.I. “UAB CF Research & Translation Core Center (Sorscher); Core B: Mouse Models Core”5/1/07-4/30/12.