Semester: Fall 2008

Credit Hours:  3

Course:  MIC 778

Title:  Primary Immune Deficiencies

Course Master(s): T. Prescott Atkinson, David D. Chaplin, Harry W. Schroeder

Description:  This course will focus on the major classes of human primary immunodeficiency disorders to reveal fundamental mechanisms of normal immune responsiveness in humans. The course will cover inherited defects of both innate and immune system function, including adhesion and chemotactic defects, myeloid cell differentiation and function defects, myeloid cell differentiation and function defects, defects of activation and regulatory complement proteins, disturbed cytolytic function in NK and CD8 T cells, impaired development of antigen-specific receptors, severe combined immunodeficincy syndromes, disorders of B and T cell development, and disturbed antigen presenting cell function. Readings will include both studies of the diseases as manifested in human patients and in animal models.  Classes will consist of an introduction to each topic followed by critical analysis of primary literature.

Prerequisites: Successful completion of the first year CMB curriculum