Lab Research Focus
My laboratory is interested in the development of B lymphocytes. Immunoglobulin gene rearrangements, as well as a number of poorly understood changes in gene expression, take place as cells progress through this differentiation pathway. We have been using both cellular and molecular approaches to characterize precursors of human B lineage cells and to identify novel genes whose expression is developmentally regulated. Defects in the expression of such genes could lead to immunodeficiency, whereas inappropriate expression might predispose a cell to malignant transformation. We have also begun to explore the function of the multifaceted cytokine, transforming growth factor-b , in regulating B cell development and function.
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