Postdoctoral Positions

A postdoctoral position is available to study the interactions between the structural domains of the HIV Gag polyprotein in polymers assembled in vitro, and in non-infectious budded particles. Amide H/D exchange as detected by mass spectrometry will be employed to detect intersubunit interfaces, and dynamic flexibility within the immature and mature virions, and relate these determinations to the available high resolution structures. This position will afford the applicant the opportunity to develop skills in state of the art mass spectrometry, protein purification, and eukaryotic molecular biology. The project is collaborative with members of the UAB Center for AIDS Research (CFAR) The UAB CFAR is a top ranked research center, with an outstanding group of interdisciplinary researchers. A Ph.D. degree in Biochemistry or Biophysics with experience in the purification and handling of proteins is preferred. This position is open immediately. Please indicate your interest by emailing: Peter Prevelige

A postdoctoral position is available to study the kinetics and thermodynamics of protein/protein interactions during the assembly of the bacteriophage P22. Bacteriophage P22 is a model system for the assembly of dsDNA containing viruses, as well as for the control of form determination in the assembly of supramolecular assemblies. The project will involve the use of calorimetry, surface plasmon resonance, small angle X-ray scattering and and spectroscopic techniques (CD, fluoresence) to characterize the interactions between the coat and scaffolding protein molecules during capsid assembly. This project involves a number of active and productive collaborations including cyro-electron microscopy, Raman spectroscopy, and NMR. A Ph.D in Biochemistry or Biophysics with experience in purification and handling of proteins is preferred. The position is open immediately. Please indicate your interest by emailing: Peter Prevelige

Research Assistant

A position is available for a research assistant. The successful candidate is expected to take a leadership role in a laboratory investigating the assembly of viral capsids. The duties include general microbiology, protein purification, DNA sequencing, as well as general laboratory tasks. The ideal candidate will a BA or BS in microbiology, chemistry, or biochemistry, and some laboratory experience in microbiology and/or biochemistry, This is an ideal position for a recent graduate interested in improving their skill set with an ultimate eye towards a biotechnology position. If you are interested in this position please contact Dr. Peter Prevelige UAB Dept. of Microbiology, BBRB 416/6 845 19th St. South, Birmingham AL. Email:prevelig@uab.edu, FAX 205 975 5479