We are interested in the underlying structural basis by which HIV proteins interact with cellular constituents during the virus replication cycle. A major component of our research program is directed towards understanding key protein-protein and protein-membrane interactions that are essential for viral replication. We employ a set of biochemical, biophysical, structural biology and in vivo tools to elucidate molecular mechanisms governing virus-host interactions. Another aspect of our research is to identify small molecule inhibitors that are able to block virus-host protein-protein complexes and ultimately serve as potential anti HIV drugs.