Post-Transcriptional Regulatory Mechanisms
Advanced Course MIC 759 - Fall Semester 2008

Coursemasters: Peter Burrows and David Bedwell

General comments: this three-credit course will split time between faculty lectures, student presentations, and in-class discussions.

Class Schedule: 90 minute class meetings will be held from 2:00 PM-3:30 PM on Tuesdays and Thursdays each week in McCauley conference room (BBRB 263).

Grading: Attendance (class and seminar), class participation, quality of student presentations (click here for schedule), grant proposal (10 page) (click here for grant proposal guidelines), and study section participation to review grants (click here for general and specific review guidelines).
Class #
Date
 Discussion Topic Presenter
1
 08/21/08 Organizational Meeting [PPT] Bedwell/Burrows
  
      
2
 08/26/08 Translational Regulation Thompson
  
      
3
 08/28/08 Translational Regulation Papers Thompson
  
   
Reviews: Nature Reviews Mol. Cell Biol. 2004
  Annu. Rev. Biochem. 2004
  Nature 2005
Primary Research Articles:
  Amrani et al., Nature, 2008
Braunstein et al., Mol. Cell 2007
Deng et al., Genes Dev. 2008
Pisarev et al., EMBO J. 2008
Pisarev et al., Cell 2007
Terenin et al., Nat. Struct. Mol. Biol. 2008
 
       
4
 09/02/08 Translational Regulation Papers Thompson
  
  
Reviews:
   
Primary Research Articles:
   
 
       
5
 09/04/08 Cytoplasmic mRNA Turnover Keeling
   
      
6
 09/09/08 Cytoplasmic mRNA Turnover Papers Keeling
  
  
Reviews:
   
Primary Research Articles:
   
 
       
7 
 09/11/08 Cytoplasmic mRNA Turnover Papers Keeling
  
  
Reviews:
   
Primary Research Articles:
   
 
       
8
 09/16/08 MicroRNAs and Gene Silencing Burrows
        
9
 09/18/08 MicroRNAs and Gene Silencing Papers Burrows
  
  
Reviews:
   
Primary Research Articles:
   
 
       
10
 09/23/08 MicroRNAs and Gene Silencing Papers Burrows
  
      
11
 09/25/08 Nuclear mRNA Surveillance Bedwell
        
12
 09/30/08 Nuclear mRNA Surveillance Papers Bedwell
  
  
Reviews:
   
Primary Research Articles:
   
 
       
13
 10/02/08 Nuclear mRNA Surveillance Papers Bedwell
 
  
Reviews:
   
Primary Research Articles:
   
 
       
14
 10/07/08 Translational Recoding Bedwell
        
15
 10/09/08 Translational Recoding Papers Bedwell
  
  
Reviews:
   
Primary Research Articles:
   
  
       
16
 10/14/08 Translational Recoding Papers Bedwell
   
Reviews:
   
Primary Research Articles:
   
 
  
      
17
 10/16/08 ER Stress Response Hendershot
       
18
 10/21/08 ER Stress Response Papers Hendershot
   
Reviews:
   
Primary Research Articles:
   
 
  
      
19
 10/23/08 ER Stress Response Papers Hendershot
  
  
Reviews:
   
Primary Research Articles:
   
 
       
20
 10/28/08 Post-Translational Modifications Justement
  
      
21
 10/30/08 Post-Translational Modifications Papers Justement
  
   
Reviews:
   
Primary Research Articles:
   
  
        
22
 11/04/08 Post-Translational Modifications Papers Justement
   
Reviews:
   
Primary Research Articles:
   
 
       
23
 11/06/08 Protein Turnover Burrows
   
      
24
 11/11/08 Protein Turnover Papers Burrows
   
Reviews:
   
Primary Research Articles:
   
 
       
25
 11/13/08 Protein Turnover Papers Burrows
   
Reviews:
   
Primary Research Articles:
   
 
26
 11/25/08 Grant Due Bedwell/Burrows
    
      
27
 12/02/08 Study Section Bedwell/Burrows
  
      
28
 12/04/08 Study Section Meeting (if needed) Bedwell/Burrows
  
      
 
      
Click here for previous schedule