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Post-Transcriptional Regulatory Mechanisms
Advanced Course MIC 759 - Fall Semester 2008
Coursemasters: Peter Burrows and David Bedwell
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General comments: this three-credit course will split time between faculty lectures, student presentations, and in-class discussions.
Class Schedule: 90 minute class meetings will be held from 2:00 PM-3:30 PM on Tuesdays and Thursdays each week in McCauley conference room (BBRB 263).
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| Grading: Attendance (class and seminar), class participation, quality of student presentations (click here for schedule), grant proposal (10 page) (click here for grant proposal guidelines), and study section participation to review grants (click here for general and specific review guidelines). |
Schedule Revised: October 9, 2008
Please note: Effective 9/16/08 class will be held in BBRB 170.
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Class #
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Date
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Discussion Topic |
Presenter |
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1
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08/21/08 |
Organizational Meeting [PPT] |
Bedwell/Burrows |
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2
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08/26/08 |
Translational Regulation [PPT] |
Thompson |
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3
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08/28/08 |
Translational Regulation - Student Presentation [PPT] |
Alison Dean |
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Deng et al., Genes Dev. 2008 |
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Terenin et al., Nat. Struct. Mol. Biol. 2008 |
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4
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09/02/08 |
Translational Regulation - Student Presentation [PPT] |
Marla Hertz |
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Amrani et al., Nature, 2008 |
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Braunstein et al., Mol. Cell 2007 |
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5
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09/04/08 |
Cytoplasmic mRNA Turnover [PPT] |
Keeling |
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6
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09/09/08 |
Cytoplasmic mRNA Turnover - Student Presentation [PPT] |
Charu Shukla |
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Eberle et al., PLoS Biol. 2008 |
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Singh et al., PLoS Bio. 2008 |
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7
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09/11/08 |
Cytoplasmic mRNA Turnover - Student Presentation [PPT] |
Philip Webber |
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Sheth and Parker, Science 2003 |
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Yamashita et al., Nat. Struct. Mol. Biol. 2005 |
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8
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09/16/08 |
MicroRNAs and Gene Silencing [PPT] |
Burrows |
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| Reviews: |
Annu. Rev. Cell Dev. Biol. 2007 |
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Nat. Rev. Genet. 2008 |
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Cell Death Differ. 2007 |
| Primary Research Articles: |
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Ma et al., Nature 2007 |
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Tavazoie et al., Nature 2008 |
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Faghihi et al., Nat. Med. 2008 |
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Grimm et al., Nature 2006 |
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Kong et al., PNAS 2008 |
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Koralov et al., Cell 2008 |
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Reeves et al., Science 2007 |
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Robbins et al., Hum. Gene Ther. 2008 |
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Selbach et al., Nature 2008 |
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Stern-Ginossar et al., Science 2007 |
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Vasudevan et al., Science 2007 |
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Ventura et al., Cell 2008 |
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9
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09/18/08 |
MicroRNAs and Gene Silencing - Student Presentation [PPT] |
Erin White |
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Ma et al., Nature 2007 |
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Tavazoie et al., Nature 2008 |
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09/18/08 |
MicroRNAs and Gene Silencing - Student Presentation [PPT] |
Chen-Chung Lin |
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Faghihi et al., Nat. Med. 2008 |
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Reeves et al., Science 2007 |
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10
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09/23/08 |
MicroRNAs and Gene Silencing - Student Presentation [PPT] |
Chao Li |
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Kong et al., PNAS 2008 |
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Vasudevan et al., Science 2007 |
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11
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09/25/08 |
Nuclear mRNA Surveillance [PPT] |
Bedwell |
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12
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09/30/08 |
Nuclear mRNA Surveillance - Student Presentation [PPT] |
Dan Wang |
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Rougemaille et al., EMBO J. 2007 |
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Saguez et al., Mol. Cell 2008 |
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13
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10/02/08 |
Nuclear mRNA Surveillance - Student Presentation [PPT] |
Charu Shukla |
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Hilleren et al., Mol. Cell 2003 |
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Buvoli et al., PLoS One 2007 |
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Nuclear mRNA Surveillance - Student Presentation [PPT] |
Chang-Hyun Kim |
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LaCava et al., Cell 2005 |
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Vinciguerra et al., EMBO J. 2005 |
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14
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10/07/08 |
Translational Recoding [PPT] |
Bedwell |
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| Reviews: |
Mol. Cell, 2004 |
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Curr. Pharmacogenomics, 2005 |
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Optional Reference: Cell, 2002 |
| Primary Research Articles: |
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Kerem et al., Lancet 2008 |
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Herr et al., EMBO J. 2000 |
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Small-Howard et al., Mol. Cell. Biol. 2006 |
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Manktelow et al., 2005 |
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Barton-Davis et al., J. Clin. Invest., 1999 |
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Welch et al., Nature 2007 |
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15
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10/09/08 |
Translational Recoding - Student Presentation [PPT] |
Dan Wang |
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Barton-Davis et al., J. Clin. Invest., 1999 |
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Welch et al., Nature 2007 |
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16
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10/14/08 |
Translational Recoding - Student Presentation [PPT] |
Marla Hertz |
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Manktelow et al., 2005 |
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Herr et al., EMBO J. 2000 |
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17
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10/16/08 |
No Class |
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18
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10/21/08 |
Post-Translational Modifications [PPT] |
Justement |
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| Overall Reviews: |
Hunter, Mol. Cell 2007 |
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Seet et al., Nature Reviews Mol. Cell Biol. 2006 |
| Regulation of p53 |
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| Review: |
Brooks & Gu, Mol. Cell 2006 |
| Primary Research Articles: |
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Yang et al., Nat. Cell Biol. 2006 |
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Okamoto et al., Mol. Cell. Biol. 2005 |
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Lu et al., Cancer Cell 2007 |
| Activation of NF-kB |
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| Reviews: |
Gao & Karin, Mol. Cell 2005 |
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Sebban et al., TRENDS Cell Biol. 2006 |
| Primary Research Articles: |
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Ea et al., Mol. Cell 2006 |
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Wertz et al., Nature 2004 |
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Lee et al., Science 2005 |
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19
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10/23/08 |
Post-Translational Modifications - Student Presentation [PPT] |
Chao Li |
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Yang et al., Nat. Cell Biol. 2006 |
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10/23/08 |
Post-Translation Modifications - Student Presentation [PPT] |
Chen-Chung Lin |
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Lee et al., Science 2005 |
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20
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10/28/08 |
Post-Translational Modifications - Student Presentation [PPT] |
Philip Webber |
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Okamoto et al., Mol. Cell. Biol. 2005 |
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10/28/08 |
Post-Translational Modifications - Student Presentation [PPT] |
Xiaoyuan Zhu |
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Wertz et al., Nature 2004 |
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21
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10/30/08 |
The Unfolded Protein Response [PPT] |
Hendershot |
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| Reviews: |
Cell, 2001 |
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Seminars in Cell & Dev. Biol., 2007 |
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Nature Rev. Mol. Cell Biol. 2007 |
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SVNY322, 2006 |
| Primary Research Articles: |
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Yoshida et al., JCB 2006 |
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Hetz et al., Science 2006 |
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Obeng et al., Blood 2008 |
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Netherton et al., J Virol. 2004 |
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Brunsing et al., J. Biol. Chem. 2008 |
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Skalet et al., J. Biol. Chem. 2005 |
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Bernales et al., PLoS 2006 |
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Li et al., Cell Death & Diff. 2008 |
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Bischof et al., PLoS 2008 |
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Okuda-Shimizu & Hendershot, Mol. Cell 2007 |
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Hollien et al., Science 2006 |
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22
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11/04/08 |
Unfolded Protein Response - Student Presentation |
Erin White |
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Bischof et al., PLoS 2008 |
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11/04/08 |
Unfolded Protein Response - Student Presentation [PPT] |
Chang-Hyun Kim |
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Okuda-Shimizu & Hendershot, Mol. Cell 2007 |
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23
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11/06/08 |
Unfolded Protein Response - Student Presentation [PPT] |
Xiaoyuan Zhu |
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Li et al., Cell Death & Diff. 2008 |
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11/06/08 |
Unfolded Protein Response - Student Presentation [PPT] |
Alison Dean |
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Hollien et al., Science 2006 |
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25
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11/18/08 |
Grants Due |
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26
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11/25/08 |
Study Section |
Bedwell/Burrows |
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Click here for previous schedule
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