Carl F. Nathan
Publications 1997 - 2007

136.  Wheeler, M. D., S. D. Smith, G. Garcia-Cardeña, C. F. Nathan, R. M. Weiss, and W. C. Sessa. Bacterial infection induces nitric oxide synthase in human neutrophils. J. Clin. Invest. 99:110-116, 1997.

137.  Jin, F.-y., C. Nathan, D. Radzioch and A. Ding. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell 88:417-426, 1997.

138.  MacMicking, J. D., R. J. North, R. LaCourse, J. S. Mudgett, S. K. Shah and C. F. Nathan. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA. 94:5243-5248, 1997.

139.  Shiloh, M., J. Ruan and C. Nathan. Evaluation of bacterial survival and phagocyte function with a fluorescence-based microplate assay. Infect. Immun. 65:3193-3198, 1997

140.  Hickey, M. J., K. A. Sharkey, E. G. Sihota, P. H. Reinhardt, J. D. MacMicking, C. Nathan and P. Kubes. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 11:955-964, 1997.

141.  Ehrt, S., M. S. Shiloh*, J. Ruan*, M. Choi, S. Gunzburg, C. Nathan‡, C., Q.-w. Xie, and L. Riley‡. A novel antioxidant gene from Mycobacterium tuberculosis. (*, ‡: contributed equally). J. Exp. Med. 186: 1885-1896, 1997.

142.  De Groote, M. A., U. A. Ochsner, M. Shiloh, C. Nathan, J. M. McCord, M. C. Dinauer, S. J. Libby, A. Vazquez-Torres, Y. Xu, and F. C. Fang. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proc. Natl. Acad. Sci. USA.94: 13997-14001, 1997.

143.  Suh, N., T. Honda, H. J. Finlay, A. Barchowsky, C. Williams, N. E. Benoit, Q.-w. Xie, C. Nathan, G. W. Gribble and M. B. Sporn. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Canc. Res. 58: 717-723, 1998.

144.  Hierholzer, C., B. Harbrecht, J. Menezes, J. Kane, J. MacMicking, C. F. Nathan, A. Peitzman, T. R. Billiar, and D. J. Tweardy. Essential role of induced nitric oxide in the initiation of the inflammatory response following hemorrhagic shock. J. Exp. Med. 187: 917-928, 1998.

145.  Jin, F., C. Nathan, D. Radzioch, and A. Ding. Lipopolysaccharide-related stimuli induce expression of the secretory leukocyte protease inhibitor, a macrophage-derived lipopolysaccharide inhibitor. Infect. Immun. 66: 2447-2452, 1998.

146.  Chen, L., Q.-w. Xie, and C. Nathan. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates. Molecular Cell 1: 795-805, 1998.

147.  Karupiah, G., J.-H. Chen, C.F. Nathan, S. Mahalingam, and J. D. MacMicking. Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection. J. Virol. 72: 7703-7706, 1998.

148.  Karupiah, G., J.-H. Chen, S. Mahalingam, C. F. Nathan, and J. D. MacMicking. Rapid interferon g-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice. J. Exp. Med. 188: 1541-1546, 1998.

149.  Shiloh, M. U., MacMicking, J., Nicholson, S., Brause, J., Potter, S., Fang, F., Marino, M., Dinauer, M. and Nathan, C. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10: 29-38, 1999.

150.  Murray, H. W. and Nathan, C. F. Macrophage microbicidal mechanisms in vivo: reactive nitrogen vs. oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 189: 741-746, 1999.

151.  Nicholson, S. C., S. R. Grobmyer, M. U. Shiloh, J. E. Brause, S. Potter, J. D. MacMicking, M. C. Dinauer, and C. F. Nathan. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock 11: 253-258, 1999.

152.  Suh, N., Y. Wang, T. Honda, G. Gribble, E. Dmitrovsky, W. F. Hickey, R. A. Maue, A. E. Place, D. M. Porter, M. J. Spinella, C. R. Williams, G. Wu, A. J. Dannenberg, K. C. Flanders, J. J. Letterio, D. J. Mangelsdorf, C. F. Nathan, L. Nguyen, W. W. Porter, R.F. Ren, A. B. Roberts, N. S. Roche, LK. Subbaramaiah, and M. B. Sporn. A novel synthetic oleanane triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), with potent differentiating, anti-proliferative and anti-inflammatory activity. Cancer Research 59: 336-341, 1999.

153.  Jin, F.-y., C. F. Nathan and A. Ding. Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: induction of matrix metalloproteinase-9. J. Immunol. 162: 3596-3600, 1999.

154.  Grobmyer, S. S., P. S. Barie, C. F. Nathan, M. Fuortes, E. Lin, S. F. Lory, C. D. Wright, M. J. Weyant, L. Hydo, F. Reeves, M. U. Shiloh, and A. Ding. Secretory leukocyte protease inhibitor, an inhibitor of neutrophil activation, is elevated in serum in human sepsis and experimental endotoxemia. Crit. Care Med. 28: 1276-1282, 2000.

155.  Fuortes, M., Melchior, M., Han, H., Lyon, G. and Nathan, C. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J. Clin. Invest. 104: 327-335, 1999.

156.  Byrd, C. A, Bornmann, W., Erdjument-Bromage, H., Tempst, P., Pavletich, N., Rosen, N., Nathan, C. F., Ding, A. Heat shock protein 90 mediates macrophage activation by taxol and bacterial lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 96: 5645-5650, 1999.

157.  Ruan, J., G. St. John, S. Ehrt, L. Riley, and C. Nathan. NOXR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress. Infect. Immun. 67: 3276-3283, 1999.

158.  Grobmyer, S. R., R. C. Armstrong, S. C. Nicholson, C. Gabay, W. P. Arend, S. H. Potter, M. Melchior, L. C. Fritz and C. F. Nathan. Peptidomimetic fluoromethylketone rescues mice from lethal endotoxic shock: Paradoxical increase in products of caspase 1 (ICE). Molecular Medicine. 5: 585-594, 1999.

159.  Nicholson, S. C., R. T. Hahn, S. R. Grobmyer, J. E. Brause, A. Hafner, S. Potter, R. B. Devereux and C. F. Nathan. Echocardiographic and survival studies in mice undergoing endotoxic shock: Effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet activating factor. J. Surg. Res. 86: 198-205, 1999.

160. Grobmyer, S. R., E. Lin, S. F. Lowry, D. E. Rivadeneira, S. Potter, P. S. Barie, and C. F. Nathan. Elevation of IL-18 in human sepsis. J. Clin. Immunol. 20: 212-215, 2000.

161.  Bryk, R., P. Griffin and C. Nathan. Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature 407, 211-215, 2000.

162.  St John, G., N. Brot, J. Ruan, H. Erdjument-Bromage, P. Tempst, H. Weissbach and C. Nathan. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates. Proc. Natl. Acad. Sci. USA 98:9901-9906, 2001.

163.  Ehrt, S., D. Schnappinger, S. Bekiranov, J. Drenkow, S. Shi, T. Gingeras, T. Gaasterland, G. Schoolnik and C. Nathan. Reprogramming of the macrophage transcriptome in response to interferon-g and Mycobacterium tuberculosis: Signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194: 1123-1140, 2001.

164.  Bryk, R., C. Lima, H. Erdjument-Bromage, P. Tempst and C. Nathan. Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science 295: 1073-1077, 2002.

165.  Shen, C. and C. Nathan. Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. Molecular Medicine, 8: 95-102, 2002.

166.  Zhu J., C. Nathan, W. Jin, D. Sim, G. S. Ashcroft , S. M. Wahl, L. Lacomis, H. Erdjument-Bromage, P. Tempst, C. D. Wright, A. Ding. Conversion of proepithelin to epithelins: Roles of SLPI and elastase in host defense and wound repair. Cell 111: 867-878, 2002.

167.  Han, H., M. Fuortes, and C. Nathan. Critical role of the carboxyl terminus of proline-rich tyrosine kinase (Pyk2) in the activation of human neutrophils by TNF: Separation of signals for the respiratory burst and degranulation. J. Exp. Med. 197: 77-85, 2003.

168.  Schnappinger, D, S. Ehrt, M. I. Voskuil, Y. Liu, J. A. Mangan, I. Monahan, G. Dolganov, B. Efron, P. D. Butcher, C. Nathan and G. Schoolnik. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J. Exp. Med. 198: 693-704, 2003.

169.  Shi, S., C. Nathan, D. Schnappinger, J. Drenkow, M. Fuortes, E. Block, A. Ding, T. R. Gingeras, G. Schoolnik, S. Akira, K. Takeda, and S. Ehrt. MyD88 primes macrophages for full-scale activation by interferon-g yet mediates few responses to Mycobacterium tuberculosis. J. Exp. Med. 198: 187-197, 2003.

170.  Darwin, K. H., S. Ehrt, J.-C. Gutierrez-Ramos, N. Weich and C. F. Nathan. The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science 302: 1963-1966, 2003.

171.  Hisert, KB, MA Kirksey, JE Gomez, AO Sousa, JS Cox, WR Jacobs, CF Nathan, JD McKinney. M. tuberculosis counter-immune (cim) mutants identified by differential screening in immuno-deficient mice. Infect. Immun. 72: 5315-5321, 2004.

172. Darwin, K.H., G. Lin, Z. Chen, H. Li and C. Nathan. Characterization of a Mycobacterium tuberculosis proteasomal ATPase homolog. Molec. Microbiol. 55: 561-571, 2005.

173.  Rhee, K., H. Erdjument-Bromage, P. Tempst and C. Nathan. S-nitroso-proteome of Mycobacterium tuberculosis: enzymes of intermediary metabolism and antioxidant defense. Proc. Natl. Acad. Sci. USA. 102: 467-472, 2005.

174. Hisert, K. B., M. MacCoss, M. U. Shiloh, K. H. Darwin, S. Singh, R. A. Jones, S. Ehrt, Z. Zhang, B. L. Gaffney, S. Gandotra, D. W. Holden, D. Murray, and C. Nathan.. An EAL domain protein of Salmonella controls bacterial survival in mice, anti-oxidant defense, and killing of macrophages: role of cyclic-diGMP. Molec. Microbiol. 56: 5, 1234-1245, 2005.

175.  Darwin, K. H., and C. F. Nathan. Role for nucleotide excision repair in virulenceof Mycobacterium tuberculosis. Infect. Immun. 73: 4581-4587, 2005.

176.  Tian, J., R. Bryk, S. Shi, H. Erdjument-Bromage, P. Tempst and C. Nathan. Mycobacterium tuberculosis appears to lack a-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Molec. Microbiol. 57: 859–868, 2005.

177.  Han, H., A. Stessin, J. Roberts, K. Hess, N. Gautam, M. Kamenetsky, O. Lou, E. Hyde, N. Nathan, W. A. Muller, J. Buck, L. R. Levin and C. Nathan. Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils. J. Exp. Med. 202: 353-361, 2005.

180.  Tian, J., R. Bryk, M. Itoh, M. Suematsu and C. Nathan.Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of a-ketoglutarate decarboxylase. Proc. Natl. Acad. Sci. 102: 10670-10675, 2005.

181.  Nathan, C., N. Calingasan, J. Nezezon, A. Ding, S. Lucia, K. LaPerle, M. Fuortes, M. Lin, S. Ehrt, N. S. Kwon, J. Chen, Y. Vodovotz, K. Kipiani and M. F. Beal. Protection from Alzheimer’s-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.  J. Exp. Med. 202: 1163-1169, 2005.

182.  Rajashankar, K. R., Bryk, R., Kniewel, R., Buglino, J. A., Nathan, C. F., and Lima, C. D.. Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. J Biol. Chem. 280: 33977-33983, 2005.

183.  Han, H., Roberts, J., Lou, O., Muller, W. A., Nathan, N., and Nathan, C.. Chemical inhibitors of TNF signal transduction in human neutrophils point to distinct steps in cell activation. J.  Leuk. Biol. 79:147-154, 2006.

184.  Cohn, E. F., Nathan, C., Radzioch D., Yu, H., Xiang, Z. and Ding, A. Abrupt expression of TLR4 in TLR4-deficient macrophages imposes a selective disadvantage: Genetic evidence for TLR4-dependent responses to endogenous, non-microbial stimuli. J. Immunol. 176: 1185-1194, 2006.

185.  Lin, G., Hu, G., Tsu, C., Kunes, Y. Z., Li, H., Dick, L., Parsons, T., Li, P., Chen, Z., Zwickl, P. , Weich, N., and Nathan, C. Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad specificity. Molec. Microbiol. 59: 1405-1416, 2006.

186. Hu, G. Lin, G., Wang, M., Jiang, J., Dick, L. Xu, R.-M., Nathan, C., and Li, H. Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Molec. Microbiol. 59: 1417-1428, 2006.

187.  Vandal, O., Gelb, M., Ehrt, S. and Nathan, C. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow derived macrophages for the control of Mycobacterium tuberculosis in vitro. Infect. Immun. 74: 1751- 1756, 2006.

188.  Kim, Y., Zhou, P., Qin, L., Chuang, J.-Z., Lee, J., Li, C., Iadecola, C., Nathan, C. and Ding, A. MyD88-5 links mitochondria, microtubules and JNK3 in neurons and regulates neuronal survival. J. Exp. Med. In press, 2007.